The bridge is already the most expensive tolled crossing in Britain.
Now Transport Secretary Alistair Darling has approved an application from the Humber Bridge Board to raise the crossing price by 20p to £2.70, with tolls for the heaviest vehicles going up by £1.60 to £18.30.
However, the board has also been asked by the Secretary of State to think about a reduction in tolls for buses.
A public inquiry into the proposals was held in February, when it was revealed that journeys across the bridge by buses have almost halved in the last decade.
Other representations included complaints about the unfair effect of the tolls on those using the bridge to go for hospital treatment. A campaign is currently being staged demanding tolls be scrapped for those people whose journey across the bridge was for medical reasons.
The inquiry inspector said that under current law there was no option but to approve the increase.
John McGoldrick for the National Alliance Against Tolls said even before the approved increase, the bridge was already the most expensive tolled crossing in Britain.
He said: "Tolls in general are not justified as the Government collects nearly £50bn a year in taxes on roads use, but only spends one seventh of this on the roads.
"The bridge debt would have been paid off many years ago, if it hadn't been for the capitalisation of losses. This meant that though the bridge cost just under £100m to build, the debt at one stage reached £425m. In effect the current users of the bridge are paying what the Government should have borne 20 years or more ago.
"Increasing the tolls will pay off the debt quicker, but this will not benefit bridge users. In almost every case as a tolled crossing has become debt free, the Government of the day has moved the goal posts and kept the tolls."
A board spokesman said they could not yet say when the price changes would be implemented.
dave.mark@ypn.co.uk