The M62 ic closed eastbound in West Yorkshire, with widespread traffic congestion.
Police say there are long delays between Bradford and Leeds - junction 26 with the M606 (Chain Bar) and junction 27 with the M621 at Gildersome.
An earlier accident involving one car has caused the tailbacks, with travel time on the short stretch currently estimated at nearly two hours.
The congestion has spread to junction 23, the A640 at Huddersfield.
Update: All lanes were re-opened shortly before the afternoon rush-hour began, but traffic backlogs mean the journey along the stretch of the M62 is still taking an hour.