Bolton v ChelseaGary Megson has an almost fully fit squad but Chelsea have doubts about Salomon Kalou and Branislav Ivanovic.
Everton v Aston VillaEverton defender Leighton Baines is poised to return from
a calf problem. Villa goalkeeper Brad Friedel is set to make his 200th successive Premier League appearance.
Fulham v LiverpoolFulham striker Andy Johnson is still suffering from a groin problem as is Steven Gerrard who misses his third successive Liverpool match. Fernando Torres (groin) faces a late test.
Manchester Utd v Blackburn United centre-backs Nemanja Vidic and Rio Ferdinand are doubtful with calf problems and fellow defender Gary Neville is suspended. Jason Roberts is the latest Blackburn player to come down with suspected swine flu.
Portsmouth v Wigan Portsmouth welcome back Kevin-Prince Boateng, Jamie O'Hara, Mike Williamson and Tommy Smith while Wigan are missing Maynor Figueroa (knee).
Stoke v WolvesStoke goalkeeper Thomas Sorensen (flu) is set to be recalled and Wolves welcome back striker Stefan Maierhofer after suspension.
Sunderland v West HamSunderland striker Darren Bent is battling to overcome a knee problem and West Ham are without the banned Scott Parker.
TomorrowBirmingham v Man CityGoalkeeper Maik Taylor makes his first Premier League start of the season, with Joe Hart ineligible to face his parent club.