Anthony Gelling grabbed a hat-trick of tries as Wigan bounced back to winning ways by thrashing a poor Wakefield.
Wigan got off to an ideal start after just three minutes with Liam Farrell going over unopposed after collecting the ball from Joe Burgess.
Smith added a penalty after Wakefield were penalised for offside and then showed the Wildcats defence a clean pair of heels to cross the whitewash.
Wakefield were failing to conjure anything constructive and Wigan took advantage to increase their lead as Manfredi collected a ball from Joel Tomkins to force his way over in the corner.
The visitors finally got on the scoreboard through Chris Riley, although Craig Hall was off-target with the conversion.
Wigan, though, extended their lead when Joel Tomkins put a hit on Jordan Hand that caused him to spill the ball and allowed Gelling to race 40 metres to score.
The one-way traffic continued into the second half as Manfredi collected a ball from Gelling. The scrum-half missed the conversion but the Warriors led 30-4.
Wakefield managed to pull a try back as Paul McShane burrowed his way over, with Hall converting. But Warriors half-back Smith then sent Mossop over.
Seconds later Farrell broke clear to grab his second, with Smith converting both as the Warriors went 42-10 ahead.
Gelling scored his second of the night after collecting Joel Tomkins’ offload before completing his hat-trick when Wakefield made a mess of Smith’s towering bomb. Smith converted.
Wigan Warriors: Hampshire, Manfredi, Gelling, Sarginson, Burgess, Williams, Smith, Mossop, McIlorum, Clubb, J. Tomkins, L. Farrell, Bateman. Substitutes: Tautai, Patrick, L. Tomkins, C. Farrell.
Wakefield Trinity Wildcats: Owen, Riley, Arundel, Collis, Johnstone, Sammut, Hall, Scruton, Washbrook, Griffin, Lauitiiti, Ryan, D. Smith. Substitutes: McShane, Simon, Crowther, Hand.
Referee: George Stokes (RFL).