Leeds United have the ideal opportunity to make up ground in the promotion race as they face Scunthorpe United at Elland Road, with the Whites sure to be a popular selection on most of today's coupons.
Scunthorpe have collapsed since losing manager Nigel Adkins to Southampton, losing eight of their last nine matches.
The Iron's only recent successes have come away from home, but that should not trouble Leeds, who can win this Championship encounter with something to spare as long as their minds do not wander to the impending FA Cup replay against Arsenal.
Doncaster will need to be wary of one of the Championship's in-form strikers as they host Reading at the Keepmoat, where Shane Long will be looking to add to his tally of seven goals in the last six games.
With games in hand on their rivals, Rovers are very much still in the play-off chase but they must win games such as this one if they are to stay in touch.
Beaten only once at home this season, Rovers have brought in Matt Kilgallon on loan and that will make them even tougher to beat.
Sheffield United need to sort out their defence after conceding 16 goals in five games and they have the opportunity to do that at Coventry, who have scored only three goals in their last six league matches.
With neither side in any sort of form, no bet can be recommended.
Hull City have pulled away from the relegation zone and with Aaron McLean and Matty Fryatt added to their striking options, they can look forward to scoring goals more regularly as they make a belated challenge for the play-offs.
The Tigers have scored only nine and conceded just six at home, but three of their last five games have ended 3-2 so backing 'Over 2.5 Goals' against Barnsley could pay off at a decent price.
Sheffield Wednesday have a massive game in League One as they welcome Charlton to Hillsborough.
Southampton's excellent run of form has left these two clubs playing catch-up, so this really is a must-win game for the Owls if they want to be realistic contenders for an automatic promotion place.
Charlton's defence has been vulnerable lately, with seven goals conceded in two league games, and that will offer encouragement to Wednesday, who have been scoring freely at home.
Huddersfield are looking to make it four wins in succession as they travel to Walsall, who have lost seven of their 10 home league games, leading to the sacking of former Town player Chris Hutchings last week.
Town are in winning form and looked strong against Wednesday recently, but at even money they are not a good bet away from the Galpharm.
Oxford United are on a roll having won five of their last six games and will be confident of picking up another three points against Bradford, whose frailties resurfaced in their shock 3-1 home defeat to Barnet.
Peter Taylor has been unable to find any consistency and this is shown by their run of five wins and five defeats in the last 11 league games.
With this in mind, they are a team to avoid betting on.
Finally, Rotherham United host Southend United, a team who appear to fare slightly better on their travels.
Paul Sturrock's side have won their last two away games and have lost only three of the last 11, although that is unlikely to prevent many punters from seeing Rotherham as a safe bet.
Weekend's best bets
Leeds to beat Scunthorpe
Doncaster to beat Reading
Hull v Barnsley – Over 2.5 Goals
Sheffield Wednesday to beat Charlton