The Whites will be looking to bounce back from disappointing midweek loss to Everton, and will be looking for revenge after they were hammered 4-1 at Selhurst Park back in November.
Meanwhile, down in the Championship, it's all still to play for as the second-half of the season continues to unfold, with the fight for promotion and battle against relegation continuing to take fresh twists and turns in the ever-entertaining division.
Huddersfield Town will be eager to put to bed a six-match run without a win, but will face a stiff challenge against a spirited Luton Town outfit, who have performed well above expectations this season under returning manager Nathan Jones
Elsewhere, Yorkshire sides Rotherham United and Sheffield Wednesday remain locked in a fierce relegation battle which looks set to go down to the wire, while Barnsley, should they string a few wins together, could start dreaming about the play-offs.
Here's our rundown of all the latest news and transfer chat involving Leeds United, Huddersfield Town, and a number of other sides from Yorkshire and further afield: