Highways England said there had been reports of a potentially serious collision on the road between Elloughton and South Cave.
Humberside Police said its officers attended the scene this morning along with firefighters and Yorkshire Ambulance Service paramedics.
The crash involving a single vehicle took place on the westbound carriageway, the force said.
An updated shared on Twitter said: "Thankfully no serious injuries. Road will be closed shortly to facilitate recovery of vehicle."
The vehicle has since been recovered and the road is now open as normal.