Highways England said there had been reports of a potentially serious collision on the road between Elloughton and South Cave.
Humberside Police said its officers attended the scene this morning along with firefighters and Yorkshire Ambulance Service paramedics.
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The crash involving a single vehicle took place on the westbound carriageway, the force said.
An updated shared on Twitter said: "Thankfully no serious injuries. Road will be closed shortly to facilitate recovery of vehicle."
The vehicle has since been recovered and the road is now open as normal.