Veeno is set to open its doors in the city on Friday November 28, following its Leeds opening in July.
Launched in Manchester in November 2013, owners Nino Caruso and Andrea Zecchino are now speaking to investors with aims to expand to 10 locations in the next 18 months.
Mr Caruso told The Yorkshire Post: “It’s our ambition to become a national chain.
“There’s a pool of cities we’re currently looking at; depending on how things go with investors, our next launch is likely to be either Liverpool or Newcastle.”
Mr Caruso and Mr Zecchino came upon the wine cafe concept when discussing how to import part of their Italian heritage to the UK.
Veeno serves high-quality wines at pub prices, alongside small plates that complement the drinks, such as meats and cheeses.
Mr Caruso said: “It’s a place where people can really relax. It’s not a place that’s trendy, like a lounge bar.”
All three sites are between 200 and 250 sq ft. In its first year, Veeno’s Manchester cafe has seen around £250,000 in turnover.
The next 12 months will be all about “putting a solid base behind the brand”, Mr Caruso said.
“It’s about reliability, quality and value,” he added.