Mr Woodford is one of the best known and best performing fund managers in the UK.
He said: “My decision to leave is a personal one based on my views about where I see long-term opportunities in the fund management industry. My intention is to establish a new fund management business serving institutional and retail clients.”
Mr Woodford manages £33bn on behalf of Invesco Perpetual. His responsibilities will transfer to a team led by Mark Barnett over the next six months.
Invesco manages £70bn across a range of asset classes.