The groups said on Thursday that the Financial Conduct Authority and the Prudential Regulation Authority have given their blessing to the all share deal.
Investors in both firms voted overwhelmingly in favour of the deal last month.
Analyst Gary Greenwood at Shore Capital said: "The all-share combination of CYBG and Virgin Money has received regulatory approval from the FCA and PRA and is now expected to become effective on October 15. This is in line with management’s previously stated expectation for completion in the fourth quarter of 2018.
"We currently see fair value for CYBG at 345p (11 per cent upside) and for Virgin Money at 420p (14 per cent upside).
"While this is perhaps enough to begin to consider a more positive stance, we continue to see much better upside elsewhere in the domestic mainstream banking sector, with Lloyds being our preferred alternative."