Brave Riley Hoult underwent 70 days of chemotherapy treatment at Leeds General Infirmary after the devastating diagnosis in November 2014
Further intensive chemotherapy followed in April 2015 when Riley, of Middleton, also underwent a stem cell transplant.
He spent nine weeks in hospital and was transferred to the intensive care unit at LGI after being struck down with a life-threatening infection..
Riley underwent radiotherapy and immunotherapy treatment before his family were told he was cancer free in July 2015.
Riley’s mother Sophie, 25, dropped him off for his first day of reception classes at Sharp Lane Primary School in Middleton on Tuesday.
Miss Hoult, said: “I felt really proud of him after everything that he has been through over the past few years.
“When I got him to school he was fine and was doing what every other child was doing. I was fine dropping him off, but when I got home I had a cry.
“I was so happy for him because he is at school and he is having a normal life now.”
Miss Hoult said Riley still struggles to walk long distances as he becomes tired quickly.
She added: “He is an amazing little boy. He is brave and strong and is an inspiration to a lot of children out there who are going through the same thing.”
Miss Hoult shared Riley’s cancer fight story on social media sites in a bid to raise awareness of neuroblastoma.
In December 2014, TV personality Kim Kardashian sent Riley a message of support on Twitter, writing: “I’m praying for you little man.”
In February 2015, West Yorkshire Police launched an investigation after Twitter trolls mocked Riley as he fought the disease.