Eight-year-old collie Patch was taken for a walk by owner Julie Galfsky, 48, through Swirly Path in Bramley in Leeds last night.
But after Patch got home, the dog developed a serious illness and began vomiting blood.
Julie, from Armley, then rushed eight-year-old Patch to the vet where he died of multiple organ failure.
Daughter Wendy Middleton said: "He became ill yesterday evening, he vomited in front of the TV and then in the kitchen. During the night he was vomiting blood and was rushed to the vets this morning where they said to let him go because his organs were failing.
"It was awful. My mum stayed with him all the way and the vet said it was the worst case of this bug they had ever seen."
The news comes just a week after another dog owner shared the story of their beloved Alsatian becoming ill from Parvo virus.What is parvovirus? How can you avoid your dog getting Parvo?
Get your dog vaccinated immediately
Avoid any areas where unvaccinated dogs could congregate
Disinfect any areas in your garden or porch using a bleach solution