Police are appealing for witnesses following the incident where a man died.
The road was closed for around eight hours from 3.30am this morning.
A silver Vauxhall Vectra was travelling from Halifax towards Queensbury and a Mercedes Actros HGV was travelling from Queensbury towards the Halifax area.
The two vehicles collided on the A647 Queensbury Road. The driver of the Vauxhall Vectra, a male in his 30s has died as a result of his injuries.
Anyone who witnessed the collision or has any information about either of the vehicles involved is asked to contact the police via 101 quoting log number *68 of 14 December.