Sachs was buried on Thursday at 86 after battling vascular dementia for four years, according to reports.
The German-born performer reportedly died at a care home on November 23.
Cleese, 77, the co-creator of the 1970s sitcom, paid tribute to the “gentle and kind” actor, who he said perfectly portrayed the hapless Manuel.
Cleese wrote on Twitter: “Just heard about Andy Sachs. Very sad ... I knew he was having problems with his memory as his wife Melody told me a couple of years ago.
“A very sweet gentle and kind man and a truly great farceur. I first saw him in Habeas Corpus on stage in 1973. I could not have found a better Manuel. Inspired.”
Cleese said he was aware the actor had been admitted to a care home “but I had no idea that his life was in danger”.
Sachs had been a resident at Denville Hall a private care home in Northwood, west London. Staff said on Thursday night they were unable to talk about his death.
His wife of 57 years, Melody Sachs, said: “It wasn’t all doom and gloom, he still worked for two years (after his diagnosis in 2012). We were happy, we were always laughing, we never had a dull moment.
“He had dementia for four years and it wasn’t very pleasant. We didn’t really notice it at first until the memory started going.
“It didn’t get really bad until quite near the end. I nursed Andrew, I was there for every moment of it.”
She said the father-of-three, a native German speaker whose parents fled the Nazis in 1938, refused to complain about his deteriorating health.
Mrs Sachs, also 86, said her husband lost his ability to speak and write during his final few weeks and he was unable to feed himself or eat during his final days.
Sachs’ repertoire spread far beyond the role of Manuel, including playing roles such as Dr Watson in a Sherlock Holmes series and Jeeves in PG Wodehouse’s The Code Of The Woosters, both of them radio adaptations.
After Fawlty Towers, he would go on to play Ramsay Clegg in Coronation Street in 2009 - a year after the Sachsgate scandal in which Jonathan Ross and Russell Brand made a prank call to the actor on the radio about his granddaughter. But he slipped from public life as his illness took hold.
Blackadder actor and comedian Sir Tony Robinson paid tribute to his “true friend”.
He said on Twitter: “So sad that Andrew Sachs has died. A true friend and a kindred spirit.
“I still have the wonderful baby pictures he took of my children. RIP.”
Samuel West, whose mother Prunella Scales starred alongside Sachs in Fawlty Towers, added: “Creator of one of our most beloved EU migrants. Such warmth and wit; impossible to think of him without smiling.”
Comedy writer Edgar Wright said Sachs “spun comic gold as Manuel in Fawlty Towers”.