Three rifles, a shotgun and the ammunition were stolen in the burglary at the property in Cononley, near Keighley, on Friday last week.
Detectives say the firearms "could be dangerous" and are urgently trying to track down the offenders, issuing a picture of a black BMW 4x4 captured on CCTV they are attempting to trace.
The burglary occurred between 1.50pm and 2.20pm when burglars forced their way through the farm's automatic gates and broke in through the back patio door using a brick.
North Yorkshire Police said "every room was ransacked" in the raid, before the thieves ripped a gun cabinet from the wall which concealed three rifles, a semi-automatic shotgun and a quantity of ammunition.
The burglars managed to pull the safe and alarm system from the wall and stole a quantity of cash and several items of sentimental jewellery, including an Omega watch and Tiffany bracelet.
A five-stone opal ring and a distinctive gold linked-plate bracelet with silver detail depicting children holding hands were also stolen.
Detective Constable Lynn Maguire of Harrogate & Craven CID said: “These weapons could be dangerous if they fall into the wrong hands. We are carrying out a number of enquiries to track these weapons down as well as identify the offenders.
“We are appealing for anyone who saw any suspicious people or vehicles in the area at the time of the incident to come forward as a matter of urgency.
“We’d also like to hear from anyone in the village who has CCTV, dash-cam or doorbell video cameras that may have captured something – of particular interest is a black BMW X3, registration YD68 TKF, which we’d like to trace.”