At round 10.20pm, it is reported that a blue Citroen C3 and a red Peugeot Speedfighter moped were in collision in Mansfield Road, Swallownest, near to the junction with Florence Avenue.
The 16-year-old boy riding the moped sustained fatal injuries. He was named today as Joshua Tyler, from Sheffield.
It is thought that the moped was travelling along Mansfield Road heading away from Swallownest centre.
Officers would like to hear from anyone who witnessed the collision.
Please call 101 quoting incident number 1246 of 17 April 2015.