Christopher Hanson, 32, from Alwoodley, was last seen by a family member in Pool-in-Wharfedale just before 10pm yesterday.
He is described as a slim built, 5ft 9ins tall white man with a gaunt face and short dark hair. He was last seen wearing a white shirt, blue jeans and brown shoes.
Det Insp Ian Scott, of Leeds District CID, said: “Christopher’s family are very worried about him and urgently need to know that he is okay.
“We are also concerned for his welfare and would like to hear from anyone who has seen him or who knows his current whereabouts.”
Anyone with information is asked to contact the Special Operations Room at Elland Road via 101 quoting log number 1533 of June 9.