Crews were dispatched to Sandhurst Road in Harehills shortly before 8am this morning.
There had been reports of a house fire with people still trapped inside.
A fire service spokesman said crews from Leeds and Killingbeck stations carried out a thorough search of the property but found nobody in there.
They used two hose reels to put out the fire before clearing smoke with a high powered fan.
A specialist fire investigation officer has also attended to start looking into the cause.