Drivers will face delays on the M1 Northbound from Junction 40 (Wakefield).
Highways England tweeted: "#M1 northbound J40. Multi-vehicle collision blocking 4 lanes.
"Traffic slowly passing on nearside. @WYP_RPU on scene. Emergency services on the way."
The crash is likely to affect any motorists driving north to Wakefield, Leeds and beyond traveling from Wakefield, Sheffield or South Yorkshire.