Police need help finding Ellis Evans, who is 14, and believed to be in the northern area of the city.
A Humberside Police spokesperson said: "We are concerned for his safety as Ellis, who is 5ft 3ins tall and of slim build with short dark brown hair, has been missing for several days.
"Ellis also goes by the name “Birmingham” due to his distinctive Midlands accent.
"When last seen he was wearing a grey tracksuit top, green camouflage t shirt, khaki “gymking” joggers, black cap and blue trainers.
"Ellis or anyone knowing where he is should call us on 101 quoting log 384 of 10 July."