The flight, LS405, left Leeds Bradford Airport at 9.15am on Wednesday morning bound for Paphos in Cyprus.
It turned back around half an hour after take-off and diverted to Manchester Airport, where it requested an emergency landing slot.
The aircraft landed safely and passengers were transferred to another plane to continue their journey.
Jet2 confirmed that a 'fault indication' has occurred during the flight but did not provide further details. Standard procedure was followed by the pilots and crew.