Part of the A1 southbound is now closed between Barton and Scotch Corner following a crash today (Wednesday).
The collision, involving a lorry, happened at about 5.30am.
Highways England officers are now on scene but motorists have been warned of heavy delays until the early evening.
A North Yorkshire Police spokesperson said: "The incident resulted in a large fuel spillage on the road causing major traffic pile up and delays.
"The driver sustained a minor cut to his head and was taken to Darlington Hospital for treatment."
Police said the road will remain closed until the early evening for resurfacing work.