He is thought to have suffered a 'medical episode' when the collision happened on Wingfield Road, Hull, at around 10pm yesterday (Monday).
Humberside Police said he was driving a black Renault Trafic minibus and have appealed for witnesses to come forward.
A police spokesperson said: "The 55-year-old was taken to hospital where he was sadly pronounced dead. It’s thought he had suffered a medical episode.
"No one else was hurt in the collision."