The house, in Camblesforth near Selby, was reported to be on fire shortly after 5am on Sunday morning.
The blaze was brought under control shortly before 7.30am and emergency services are still in attendance, damping down and ensuring safety on the scene.
North Yorkshire Police said that investigations will commence once the scene has been made safe, and appealed for information.
"If you have any information which could help the investigation, please call 101, press option 1 and ask for the Force Control Room," it said.
Further updates to follow.