The woman, in her forties, was attacked in her car by the man, thought to have parked his lorry on the A1079 near Dunnington, on the night of Wednesday 1 July.
Police hope fellow drivers may be able to identify the man from a description issued this morning.
He is aged around 55, 5ft 10ins, “proportionate build”, with a tattoo on his upper left arm, possibly an anchor, and blond or light hair.
He is believed to have been driving a large lorry similar to an HGV, cream or white in colour, with red lettering on the side including the letters ‘D’, ‘E’.
The attack took place around midnight on Wednesday 1 July, and the lorry is believed to have been parked in the layby overnight.
Extensive police enquiries are ongoing to identify the man.
DCI Dave Ellis, of North Yorkshire Police’s Major Crime Unit, said: “This attack was on a vulnerable woman who, due to her personal circumstances, spent the night in her car in this layby, where she was raped by a stranger.
“This man is believed to be a lorry driver, and I am appealing for the public to help us identify him. In particular, I believe that fellow drivers may recognise the description of this man, or of his lorry, and will be able to provide information which will help to identify him.”
Call 101 or Crimestoppers on 0800 555 111.