Leslie Wheatley, aged 50, was last seen at his home in Moortown at around 10pm.
He is described as a white male, with mousey brown hair and a bit of stubble. He has a silver ring in his eyebrow, cross tattoo on his arm and tattooed dots on his knuckles.
Det Sgt Sarah Jenness of Leeds CID said: ‘We are concerned for Leslie’s well-being as he may be in need of medication. We would ask him or anyone who has knowledge of his whereabouts to contact police on 101 quoting log 2312 of 27/7."