The motorway was shut eastbound due to the multi-vehicle collision between junctions 25 and 26, close to Hartshead Moor services.
All lanes are now reopen but motorists have been told to expect severe ongoing delays that could add as much as 90 minutes to their normal journey time.
A Highways England spokesman said: “If you’re planning on using this section of the M62 please allow plenty of extra time for journeys and consider alternative routes if possible.
“Alternatively please consider delaying your journey until the incident has cleared and traffic conditions have eased.”
At least one vehicle is reported to have overturned in the collision.