Stem cell link to ‘higher thinking’

Scientists have identified a family of stem cells that may give birth to neurons responsible for abstract thought and creativity.

The cells were found in embryonic mice, where they formed the upper layers of the brain’s cerebral cortex. In humans, the same brain region allows abstract thinking, planning for the future and solving problems.

Previously it was thought that all cortical neurons – upper and lower layers – arose from the same stem cells, called radial glial cells.

The new research shows that the upper layer neurons develop from a distinct population of diverse stem cells.

In mammals, the cerebral cortex is built in onion-like layers of varying thickness. The thinner inside layers host neurons that connect to the brain stem and spinal cord to regulate essential functions such as breathing and movement.

The larger upper layers, close to the brain’s outer surface, contain neurons that integrate information from the senses and connect across the two halves of the brain.

Higher thinking functions are seated in the upper layers, which in evolutionary terms are the “newest” parts of the brain.

The new research is reported today in the journal Science.

Growing the stem cells in the laboratory could pave the way to better treatments for brain disorders such as schizophrenia and autism.