Following last week's Supreme Court ruling and the publication of the Government's European Union (Notification of Withdrawal) Bill, this week will be all about the triggering of Article 50.
The Leader of the House has allocated two days this week for the second reading stage of the legislative process - followed by three days in committee stage the following week - to allow closer scrutiny of the Bill and the many proposed amendments.
The pressure will be on for Labour MPs who have not yet confirmed how they will vote, as they face a three-line whip from leader Jeremy Corbyn to back the Government's Brexit timetable.
Meanwhile the Lib Dems have confirmed they will table an amendment calling for a second referendum on the final deal, and the SNP will look to vote the Bill down.
Monday January 30
The week kicks off at the usual time of 2.30pm with questions to the Secretary of State for Defence.
Tory check MPs seems to be lining up to ask the ministers what conversations they have been having with fellow NATO members about the commitment to spending 2 percent of GDP on defence - which suggests they have had indeed had such conversations.
This could be an attempt to distract from the inevitable questions about last week's revelations concerning a failed Trident missile fire, as Independent MP Natalie McGarry calls for an independent inquiry.
This will be followed by the second reading of the Pensions Bill, which aims to introduce protections for workers enrolled on multi-employer pension schemes, and cap early exit charges.
Meanwhile over in Westminster Hall MPs will debate a petition on pay restraints imposed on NHs Agenda for Change staff, who have reportedly suffered a 14% cut in real terms pay since 2010.
And in select committees, the latest session of the Communities and Local Government inquiry into the state of adult social care promises to be interesting, as MPs have a chance to grill DCLG minister Marcus Jones, health minister David Mowat, and work and pensions minister Penny Mordaunt.
Tuesday January 31
The Commons meets at 11.30am for questions to the Secretary of State for Business, Energy and Industrial Strategy. This might see some follow up questions to last week's publication of the Government's delayed industrial strategy green paper.
This is followed by a ten minute rule motion by the Tory MP Nusrat Ghani calling for a ban on official usage of the term "honour killing" in favour of formal classifications of "aggravated murder of" and "aggravated domestic violence against" women.
Then comes the first day of debate for the second reading of the Government's Brexit Bill, which has seen MPs from across the opposition benches table multiple amendments aimed at blocking its progress . This includes reasoned amendments from the Lib Dems, Greens, SNP and Labour - despite the three line whip from leader Jeremy Corbyn.
Outside the main chamber, Diana Johnson leads a Westminster Hall debate on statutory sex and relationships education in state funded schools. This is an issue that the heads of some of Parliament's most influential select committees have been raising for some time, so could see the Government face criticism from MPs on its own side.
Meanwhile, the Education Select Committee will be grilling education minister Nick Gibb over the Government's controversial plans for school funding reform. Although this is likely to mean £100m boost for schools in Yorkshire, it will see other areas lose out as a result of attempts to balance out spending. MPs may also raise the issue of real terms cuts to the overall schools budget.
This will be followed by an adjournment debate on school funding in Greater London.
Wednesday February 1
Business begins at 11.30 with questions to the Secretary of State for Northern Ireland, followed by the weekly face-off between Theresa May and Jeremy Corbyn at PMQs.
The Tory MP Peter Aldous will then bring forward his ten minute rule motion calling for petrol stations to advertise how much tax their customers are paying on fuel.
Afterwards, MPs will continue their debate for the second reading of the Brexit Bill, including a vote on the Government's timetable for the legislation to pass through the Commons, which has come under heavy criticism from Labour and SNP MPs. If the Bill passes, it will move to Committee stage and a final vote next week.
Over in Westminster Hall, the Tory MP Lucy Allan will lead a debate on the implementation of the Government's Prevent Strategy. Ms Allan has previously raised concerns about the application of the counter-terrorism programme in schools
Meanwhile, the European scrutiny committee will be taking evidence from the outgoing ambassador to the EU, Sir Ivan Rogers, about EU-UK relations in preparation for Brexit. Sir Ivan ruffled more than a few feathers in Westminster when his scathing resignation letter was leaked earlier this month.
The day ends with an adjournment debate led by the SNP MP Tasmina Ahmed-Sheikh to mark World Hijab Day.
Thursday February 2
MPs gather in the Commons bright and early at 9.30am for questions to the Attorney General (will they be pressing for further details about the recent Supreme Court ruling?), followed by questions to the Minister for Women and Equalities, and the Leader of the House.
Then the main business in the chamber is a backbench debate on the 2016 Armed Forces Covenant report, which last year warned of the "poor quality of life" being experienced by service families up and down the country.
The report claimed that some families are being forced to live with “leaking roofs [and] no heating for months", and that current situation "represents a threat to recruitment and retention, as well as...morale".
In Westminster Hall MPs Fiona Bruce, Bill Esterson, Liam Byrne will lead a debate on efforts to tackle the harm caused by alcohol. And the adjournment debate will focus on raising awareness of colostomy irrigation treatments for bowel cancer patients, with the Tory MP Glyn Davies - a former cancer sufferer himself - leading the discussion.
Friday February 3
The days begins at 9.30am with the second reading of Dan Jarvis Child Poverty Bill.
Mr Jarvis has been a fierce critic of the Government's decision to axe its child poverty unit, scrap poverty reduction targets and remove income-based measures from poverty assessments.
His new private members bill seeks to reintroduce this target while also introducing a requirement for ministers to provide regular updates on their progress to Parliament.
The second piece of legislation on the order paper is Tory MP Wendy Morton's Local Authority Roads (Wildlife Protection) Bill.
This would place a statutory duty on local highways agencies and local transport authorities to put safeguards in place on roads that pass through or nearby protected areas, to reduce the risk of harm to wildlife.
The week draws to a close with an adjournment debate looking at the case of Jane Harrison, who went missing in 1995 after a trip to Wood Green shopping centre in North London. In 2013 her partner Kevin Doherty was jailed for 12 years for manslaughter.