The UK will be plunged into uncertainty and may never leave the European Union if MPs reject the Brexit deal, Theresa May said.
In a warning ahead of Tuesday's Commons showdown on her Withdrawal Agreement, the Prime Minister acknowledged "no one knows" what will happen if her plan is defeated.
The Prime Minister is urging Brussels to give ground in order to help her deal survive Tuesday's crunch vote by agreeing changes to the Northern Ireland backstop measures.
In a speech in Leave-voting Grimsby, the Prime Minister said: "Next week MPs in Westminster face a crucial choice: Whether to back the Brexit deal or to reject it.
"Back it and the UK will leave the European Union. Reject it and no one knows what will happen.
"We may not leave the EU for many months, we may leave without the protections that the deal provides. We may never leave at all."
She added: "Everyone now wants to get it done, move beyond the arguments, past the bitterness of the debate and out of the EU as a united country ready to make a success of the future."
In a plea to Brussels for support in making changes, she said what the European Union does over the next few days "will have a big impact on the outcome of the vote".
Foreign Secretary Jeremy Hunt warned Brussels that a failure to co-operate on securing changes to the Brexit deal could "poison" relations with the EU for years.
"This is a moment of change in our relationship between the UK and the EU and history will judge both sides very badly if we get this wrong," Mr Hunt told the BBC Radio 4 Today programme.
"We want to remain the best of friends with the EU. That means getting this agreement through in a way that doesn't inject poison into our relations for many years to come."
The EU said technical discussions are ongoing and it insisted Brussels has come forward with ideas to resolve the deadlock.
European Commission spokesman Alex Winterstein told reporters in Brussels: "The EU side has offered ideas on how to give further reassurances regarding the backstop. You are aware of all this."
Labour leader Jeremy Corbyn said the Prime Minisiter's speech was "a sign of desperation" and promised to oppose the deal again when it came to the Commons, instead continuing to push his own proposals for a customs union and access to the single market.
He said his party's priority was to stop a no-deal Brexit, but insisted Labour was not "backing away" from a second referendum.
"What we're saying is the priority at this moment is to stop a no-deal exit."