The M62 westbound between J26 for Chain Bar and J25 for Brighouse is currently at a temporary standstill due to the crash.
Multiple vehicles were involved in a crash shortly before 7am.
Four miles of congestion has built up - expected to add up to 45 minutes on to usual journey times.
Highways England tweeted: "If travelling in #WestYorkshire this morning pls be aware this collision #M62 westbound is causing LONG DELAYS.
"There are approx. 4 miles of congestion which is expected to add 30 - 45mins onto usual journey times. #Leeds #Huddersfield #Bradford motorists plan ahead."