The engines from Rotherham, Elm Lane, Parkway and Central stations were called to a garage repair centre at 1.50am on Saturday morning.
On arrival firefighters found the premises on Clough Road in Masbrough, Rotherham, well alight with a number of cars inside the premise.
Firefighters wearing breathing apparatus used hose reels to tackle the fire.
A small number of cars were destroyed or damaged in the incident.
An investigation into the cause of the fire will now take place.