Lofthouse Interchange (Junction 42 on the M1 and Junction 29 on the M62) is a major junction for commuters in Leeds and Wakefield.
It will be closed for eight weeks while engineers work on the junction
The junction’s free flow link roads, which don’t require drivers to use the roundabout, will remain open.
Signed diversion routes will be in place for all affected traffic.
The closures are part of a £3.6million project on the roundabout's four bridges.
Highways England said the roundabout has been shut so that the "work can be completed in the shortest time possible".
Highways England project manager, Russell Mclean said: "Our team of engineers have worked hard to get this work underway during this period when there were fewer vehicles on the roads.
"We understand completely that this work is going to have a large impact on drivers and we ask that drivers plan their journeys when travelling in the area.”
"This complex engineering project on one of Yorkshire’s biggest structures is necessary to maintain a route that is key in supporting the region’s economy.
"It will also reduce disruption in the long term, as the improvements reduce the need for future repairs."
Diversion routes for all affected traffic
The closure will mean that anyone wishing to travel in the following directions will need to follow a signposted diversion route:
M1 northbound to M62 eastbound
M62 eastbound to M1 southbound
M62 westbound to M1 northbound
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