It is believed that the girls may have travelled together by train from East Yorkshire to the Shrewsbury area yesterday.
Amber is described as white, 5ft 10ins tall, of slim build with straight shoulder length dark blonde hair and a nose piercing. When she was last seen, she was wearing black skinny jeans and a white strappy top and was carrying a large cream handbag.
Kayleigh is described as white, 5ft 6ins tall, of slim build with long dark hair. She was last seen wearing a turquoise suede jacket, cream vest top, black jeans and grey and black trainers and was wearing her hair up.
If you have seen the girls, or know where they are, please call Humberside Police on 101 quoting log number 424 of 22 July 2018. Alternatively you can report information anonymously via Crimestoppers by calling 0800 555 111.