Chloe Brannan from Bradford was last seen in the Great Horton Road area at about 5pm and may have been in Saltaire yesterday evening.
She is described as white 5ft 5ins tall, very slim, and has below shoulder length dark brown hair, with the bottom of her hair dyed gingery blonde.
She was last seen wearing a red sleeveless crop top, pale grey zip up jacket and Khaki green jacket over that. She was also wearing dark ripped jeans, black and white Nike trainers and a slate blue shoulder bag.
DI Paula Bickerdyke of Bradford District CID, said: "Chloe is vulnerable and we have concerns for her welfare. Enquiries are ongoing to locate Chloe who often hangs around the Bradford city centre and Idle areas.
"I would ask Chloe or anyone who has information about her whereabouts to contact Bradford District CID on 101 referencing log number 1236 of Friday May 27th."