Emergency services were called to a house in Orgreave Lane on Thursday morning after reports that a man had been seriously injured.
The victim, who has been identified as Alan Grayson, 85, was pronounced dead at the scene. He died from stab wounds, a post-mortem examination concluded.
Marjorie Grayson has been charged with murder and remanded in custody. She was due to appear before Sheffield Magistrates' Court this morning.
There was no further detail from police about how the two were connected.
Detective Inspector Simon Palmer, the senior investigating officer, said: "Mr Grayson's family are being supported by specialist officers during this incredibly difficult time and have asked that their privacy is respected.
"I fully appreciate that Mr Grayson's death is highly emotive but I would urge people to think about comments they make on social media and the impact it could have on the family.
"I'd also like to ask that people refrain from posting speculations, to enable criminal proceedings to progress through the courts unhindered and to allow the family time to grieve."