Barcelona in Arsenal's way, Spurs head back to Milan
Tottenham Hotspur return to Milan to face AC while Manchester United have been drawn against Marseille and Chelsea meet Danish side Copenhagen.
The draw for the last 16 of the Champions League is:
Roma v Shakhtar Donetsk
AC Milan v Tottenham
Valencia v Schalke
Inter Milan v Bayern Munich
Lyon v Real Madrid
Arsenal v Barcelona
Marseille v Manchester United
FC Copenhagen v Chelsea
The first legs will be played on February 15/16/22/23 with the second legs on March 8/9/15/16.
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Hide AdManchester City will face Greek side Aris Thessaloniki in the first knock-out stages of the Europa League while Liverpool will take on Sparta Prague.
Both Premier League sides should be confident of making the last 16 following today's draw, but Rangers have a tougher-looking test against Sporting Lisbon.
Roberto Mancini's City will be aware however that Aris stunned the holders Atletico Madrid in the group stage - winning 3-2 away, a result which ultimately knocked the Spanish side out of the competition.
Liverpool may have been the draw specialists in the group phase, having tied four of their six games, but in Sparta they will face a side who have proved equally difficult to beat, having drawn three of their group matches.
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Hide AdIf they get through, City will face Besiktas or Dynamo Kiev in the last 16, while Liverpool would face Lech Poznan or Braga. If Rangers progress, they would face Lille or PSV Eindhoven.
The draw for the round of 32 in the Europa League is:
Napoli v Villarreal
Rangers v Sporting Lisbon
Sparta Prague v Liverpool
Anderlecht v Ajax
Lech Poznan v Braga
Besiktas v Dynamo Kiev
Basle v Spartak Moscow
Young Boys v Zenit St Petersburg
Aris Salonika v Manchester City
PAOK v CSKA Moscow
Sevilla v Porto
Rubin Kazan v FC Twente
Lille v PSV Eindhoven
Benfica v Stuttgart
BATE v Paris St Germain
Metalist Kharkiv v Bayer Leverkusen
The draw for the round of 16 in the Europa League is:
Benfica/Stuttgart v BATE/Paris St Germain
Besiktas/Dynamo Kiev v Aris Salonika/Manchester City
Rubin Kazan/FC Twente v Young Boys/Zenit St Petersburg
PAOK/CSKA Moscow v Sevilla/Porto
Lille/PSV v Rangers/Sporting Lisbon
Metalist Kharkiv/Bayer Leverkusen v Napoli v Villarreal
Anderlecht/Ajax v Basle/Spartak Moscow
Sparta Prague/Liverpool v Lech Poznan/Braga