O’Toole, who only found out about a change of opponent on the day of the fight, lost out to Simpson, who he had previously fought twice.
The Scarborough man won the first round, using his superior jab and boxing skills to stay away from Simpson’s advances.
However, Simpson used his strength and experience to take the second and third rounds to pick up the win and the title.
Westway prospect Lewis Spaven produced a slick display to edge out Boldon ABC’s Lee Gordon in Newcastle.
The 15-year-old light-welterweight was quickly the dominant fighter in the first round, catching Gordon with his southpaw right hand, which he followed with an accurate and whipping hook that resulted in a standing count.
Gordon recovered but had to survive a tricky finale to the round as Spaven peppered him on the ropes.
The home man was more cautious in the second round, but Spaven still landed a number of times, before again shaking his opponent in the third to take a unanimous points win.
Thirteen-year-old Justin Rudd was on the receiving end of a home decision, despite dominating most of his fight against Anthony Johnson.
Coach George Rhodes said: “We were very pleased with his performance. He should have won the fight.”