Former Leicester playmaker Ford is the only change to Lancaster’s EPS, with Freddie Burns keeping his place alongside first-choice fly-half Owen Farrell.
England head coach Lancaster said: “We have kept changes to a minimum because we believe this squad can take us forward into 2015.
“I am delighted for George, who is rewarded for his form for Bath and we are excited about including him in the senior Elite Player Squad.”
Leicester fly-half Flood will join Toulouse in the summer, and England do not select overseas-based players.
So Lancaster has chosen to jettison the former Newcastle man now rather than in the summer.
Flood’s England career therefore appears to be over after winning 60 caps, while former Leicester man Ford steps into the squad on a full-time basis.
Lancaster has made only one official change to his EPS, but eight England Saxons stars are set to make senior England appearances during the RBS 6 Nations.
With injury concerns surrounding a host of senior England men, Lancaster has taken the option to promote a host of second-string men on a short-term basis.
Northampton’s Luther Burrell, Exeter duo Tom Johnson and Jack Nowell, Jonny May from Gloucester and Matt Mullan from Wasps are all among that eight.
Leicester’s Ed Slater, Sale prop Henry Thomas and Bath’s young wing Anthony Watson complete the set.
Props Mullan and Thomas step up to cover tighthead David Wilson’s calf injury which could sideline him for a month, the majority of the Six Nations tournament.
Lancaster has promoted these eight Saxons as cover for Manu Tuilagi, Tom Croft, Marland Yarde, Alex Corbisierio, Christian Wade, Geoff Parling and Ben Foden, as well as the doubt over Wilson.
Northampton’s Stephen Myler, Bath hooker Rob Webber and Saracens scrum-half Richard Wigglesworth will also train with the senior squad.
Lancaster confirmed he has retained his injured crew of players with a hope he can take them on England’s summer tour to New Zealand.
The England boss admitted he could not reasonably select Flood, despite pleading with the 28-year-old not to move to France in the summer.
Lancaster said: “We are hopeful that some of those injured may be available before the end of the Six Nations and certainly for the (summer) New Zealand tour.
“I have met Toby Flood several times and told him I really wanted him to stay at Leicester and play for England.
“He has made a lifestyle choice and we respect that, but given the RFU’s policy of not selecting players based overseas save for exceptional circumstances it was important that we allow others such as George Ford to progress.
“Stephen Myler has a chance to lay down a marker when he trains with us while we have decided that Freddie Burns should get more international game time with the Saxons against the O2 Ireland Wolfhounds at Kingsholm on January 25, while Rob Webber and Richard Wigglesworth will give us some depth to our training.”
England: Forwards - Attwood (Bath), Cole (Leicester), Hartley (Northampton), Kvesic (Gloucester), Johnson (Exeter), Launchbury (Wasps), Lawes (Northampton), Marler (Harlequins), Morgan (Gloucester), Mullan (Wasps), Robshaw (Harlequins), Slater (Leicester), Thomas (Sale Sharks), B Vunipola (Saracens), M Vunipola (Saracens), Webber (Bath), Wood (Northampton), Youngs (Leicester)
Backs - Ashton (Saracens), Barritt (Saracens), Brown (Harlequins), Burrell (Northampton), Care (Harlequins), Dickson (Northampton), Eastmond (Bath), Farrell (Saracens), Ford (Bath), Goode (Saracens), May (Gloucester), Myler (Northampton), Nowell (Exeter), Twelvetrees (Gloucester), Youngs (Leicester), Watson (Bath), Wigglesworth (Saracens).