The out-of-favour forward is in line to move to Gresty Road until January after Leeds reached a deal in principle with Crewe.
Ajose has been made available by United head coach Neil Redfearn just four months after joining Leeds in a £150,000 transfer from Peterborough United.
The 23-year-old - a target of former United boss David Hockaday - signed a three-year contract in August but has drifted away from the first-team picture after only a handful of appearances.
Crewe are bottom of League One after taking just 15 points their first 18 matches and have targeted new strikers after averaging less than a goal a game.
Ajose is one of several players who Redfearn is looking to move out of Thorp Arch before tomorrow’s deadline.