The Whites will be looking to bounce back from disappointing midweek loss to Everton, and will be looking for revenge after they were hammered 4-1 at Selhurst Park back in November.
Meanwhile, down in the Championship, it's all still to play for as the second-half of the season continues to unfold, with the fight for promotion and battle against relegation continuing to take fresh twists and turns in the ever-entertaining division.
Huddersfield Town will be eager to put to bed a six-match run without a win, but will face a stiff challenge against a spirited Luton Town outfit, who have performed well above expectations this season under returning manager Nathan Jones
Elsewhere, Yorkshire sides Rotherham United and Sheffield Wednesday remain locked in a fierce relegation battle which looks set to go down to the wire, while Barnsley, should they string a few wins together, could start dreaming about the play-offs.
Here's our rundown of all the latest news and transfer chat involving Leeds United, Huddersfield Town, and a number of other sides from Yorkshire and further afield:
1. Hatters eye Edwards
Luton Town boss Nathan Jones has admitted he's interested in signing West Bromwich Albion forward Kyle Edwards. The ex-England youth international has made five Premier League appearances for the Baggies so far this season. (Luton Today) Photo: GLYN KIRK
2. Terry closes in on Bournemouth job
John Terry has become the odds-on favourite to become the next manager of Bournemouth. He looks let to leave his assistant role at Aston Villa to take over the Cherries. (SkyBet) Photo: JOHN WALTON
3. Lions still want Hibs star
Millwall boss Gary Rowett has hinted that his club could resume their interest in signing Hibs defender Ryan Porteous in the summer, after having an offer knocked back last month. They were also keen on Motherwell's Allan Campbell. (London News Online) Photo: Ian MacNicol
4. Barnsley boss rejoices end of January
Barnsley manager Valerien Ismael has revealed he's "overjoyed" the transfer window is now closed, as his club came close to losing a key player late on on deadline day. (The 72) Photo: George Wood