The Whites were sunk by goals from Danny Welbeck and Pascal Gross on the South Coast, and fell out of the top half as a result.
Their last clash against Spurs ended in similarly underwhelming circumstances, with goals from Harry Kane, Son Heung-Min, and Toby Alderweireld ultimately handing the north Londoners a 3-0 victory.
This time around, Tottenham will be bidding to keep their hopes of a Champions League finish alive, but Marcelo Bielsa has made it clear that he believes his side have shown enough consistency in recent weeks to prove that they can cause Spurs problems.
Speaking in a press conference on Thursday, he said: "We have already showed this with continuity, six games prior to the defeat against Brighton indicated an even performance that we gave - unless we consider the defeat against Brighton a significant alteration in our own form and I don't think it is this way.
"I don't think so because I look at the performance levels of teams in a similar position to ours and there isn't one who doesn't have a poor performance level between every five or six games.
"Apart from two or three teams, every team has gone through this situation."
Prior to their defeat at Brighton, Leeds have put together a run of six unbeaten matches.
We’ve gathered the best of today’s Premier League transfer speculation involving the Whites and the rest of their top flight rivals below:
1. Brighton want Hamer
A handful of teams, including Brighton and Rangers, are looking at Coventry City’s Gustavo Hamer ahead of this summer’s transfer window. (Football League World) (Photo by Nathan Stirk/Getty Images)
Photo: Nathan Stirk
2. Palace winning Tufan race
Crystal Palace are to complete a move to sign Fenerbahce midfielder Ozan Tufan this summer, despite suggestions that Leeds United are also interested. (Fanatik) (Photo by Matthias Hangst/Getty Images)
Photo: Matthias Hangst
3. Mourinho eyes De Gea reunion
Jose Mourinho is plotting a reunion with Manchester United goalkeeper David De Gea at AS Roma next season. (Corriere Dello Sport) (Photo by Stu Forster/Getty Images)
Photo: Stu Forster
4. Rangers hold 'huge' Kent advantage
Rangers have a “huge” advantage over most English clubs as they can offer Ryan Kent Champions League football and trophies, according to Paul Robinson. Leeds United are said to be keen on the winger. (Football Insider) (Photo by Ian MacNicol/Getty Images)
Photo: Ian MacNicol