The Tigers were beaten 3-1 by Yorkshire neighbours Doncaster Rovers and have now gone 29 games without a victory away from home.
Manager Pearson was unable to attend the game after spending Friday night in hospital following a health scare.
A statement from the Tigers said the former Sheffield Wednesday and Middlesbrough defender, 47, was expected to return home on Saturday night and return to work on Monday.
Goals from Martin Woods, Billy Sharp (penalty), and James Coppinger secured the points after Nick Barmby had levelled in the first half.
Woods had put Rovers ahead with a header after just 65 seconds before Barmby, who had not scored since January 2009, levelled after nine minutes.
Sharp's penalty restored Rovers' lead just before the break after defender Liam Cooper was adjudged to have handled at a corner.
Coppinger wrapped things up for Rovers in the 70th minute with a neat finish after exchanging passes with Woods.
Australian winger Richard Garcia was denied a late consolation for Hull when his header was hacked off the line by James O'Connor.
Welcome to the Yorkshire Post's exciting match-day service, called Match Centre. Here you will find minute-by-minute updates, stats and team formations. Plus reports from every game in England, from the Premier League down to the Blue Square Premier.
Simply select your game from the pull down menu, then click on the 'i' information button on the right of the fixture and it will give you access to everything you need to know about your team.
So if you can't make it to a game, head for the Match Centre and we will give you the best seat in the house. Click the link below.
For the latest team news, score and commentary from your team check out our new Match Centre