Sheffield United were praised as the best side in League One after Uwe Rosler saw his Brentford side take all three points from the Blades.
Clayton Donaldson put the home side ahead from close range in the third minute, before Harry Forrester drilled in a terrific effort to double the lead.
Home keeper Simon Moore pulled off a number of fine saves after the break, while Marcello Trotta had an effort ruled out for offside for the Bees.
The Blades slip to fourth in the table, while Brentford move up to fifth.
Brentford boss Rosler said: ”Today we played the best team in the league.
“The way we played in the first half was unbelievable but we got a little bit tired in the second half.
“The average age of our team today was twenty two and a half.
“I have so much respect for my players and what they showed this week and today.”