Sheffield United, the last remaining Yorkshire side in the Capital One Cup and the FA Cup semi-finalists five months ago, have been drawn at MK Dons in the last 16.
Nigel Clough’s Blades will face their League One rivals on either October 28 or 29.
MK Dons knocked out Bradford in the third round while United booked their place in the last 16 with victory over Leyton Orient.
Fourth round draw
Tottenham v Brighton
Stoke v Southampton
Bournemouth v West Brom
Shrewsbury v Chelsea
Liverpool v Swansea
MK Dons v Sheff Utd
Man City v Crystal Palace/Newcastle
Fulham v Derby
Ties to be played October 28-29.