Defenders Harry Maguire and Matt Lowton return after serving one game bans but Lecsinel Jean-Francois (knee) is out for the season.
Midfielder Kevin McDonald (hamstring) is still ruled out.
The Blades were in front after just six minutes, top scorer Ched Evans firing home.
And the Wales striker was on the scoresheet at the start of the second half to increase the Blades’ advantage,
Brentford: Moore, Logan, Dean, Legge, Bidwell, Diagouraga, Saunders, Forshaw, Douglas, Berahino, Donaldson. Subs: Lee, Weston, McGinn, Osborne, Thompson.
Sheff Utd: Simonsen, Lowton, Maguire, Hill, Williams, Hoskins, Doyle, Williamson, Quinn, Evans, Porter. Subs: Howard, Montgomery, Beattie, Cresswell, Egan.
Referee: Christopher Sarginson (Staffordshire)
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