This weekend the Blades host Brighton at Bramall Lane, while their Champions League qualification rivals Spurs and Chelsea face off in an eagerly-anticipated London derby. Here's our mini-preview of the weekend's action.
1. Chelsea v Spurs
It's the battle of the backup strikers, with both sides missing key men up top. With Tammy Abraham a doubtful starter and Harry Kane out, it will be up to Michy Batshuayi and Lucas Moura to be their sides' respective heroes.
2. Leicester City v Manchester City
The Citizens are battling on despite their shock two-year expulsion from Europe, Pep Guardiola has claimed he has no doubts over his players' loyalty, despite Raheem Sterling being linked with Real Madrid.
3. Manchester United v Watford
The Red Devils are in fine spirits after their 2-0 win over Chelsea last weekend, and they'll be eager to push on in their bid to secure Champions League football. They'll be hoping Scott McTominay is back to face the Hornets.
4. Wolves v Norwich City
The Canaries are also in real danger of going down, but their boss Daniel Farke is talking tough ahead of the Wolves game. He's claimed that there's no chance his side are raising a white flag any time soon.