Owls captain Rob Jones was suspended so loan signing Miguel Llera made his debut at the centre of defence. Striker Ryan Lowe replaced the injured Gary Madine while defenders Lewis Buxton, Jon Otsemebor, and Daniel Jones are all sidelined.
Sanchez Watt had to sit out the match, the Arsenal striker the unlucky one of six loan players at Megson’s disposal. League rules mean only five loan players can be included in the matchday 16.
The Owls took the lead on 18 minutes. A short free-kick was floated to the back post by Ben Marshall where left-back Reda Johnson headed home.
Chris O’Grady’s header was hacked off the line in the second half but the Owls held on for all three points after some late Orient pressure.
Gary Megson said: “We’ve talked all week about the importance of this game and that was a hard-fought win.
“With Charlton and Huddersfield playing each other on Monday, we needed the win and I’m really pleased we got it.
“It’s all about winning when you play for Sheffield Wednesday. I don’t want to be talking to the Press after any game saying we played well, we are improving, but only having drawn the game.
“Leyton Orient are a good side, they have now lost only one game in eleven and our players can take a lot of credit.”
For reaction and big-match report from today’s game, read Sports Monday, free with Monday’s Yorkshire Post newspaper.