The Cherry and Whites were swept away at an emotional Sandy Park by the Premiership newcomers and Back has been preparing his team all week for the expected backlash.
"There was a lot made of Exeter's win, but it was an extremely tough match for Gloucester," said the head coach who along with director of rugby Andy Key signed a one-year contract extension this week.
"Everything was in Exeter's favour for a big day for them and credit to them they got the win.
"However, Gloucester missed opportunities and, like ourselves, I am sure they have been concentrating this week on finishing off those chances."
Injuries to pivotal players have forced Back and Key to make five changes to the side that lost to Bath. Influential fly-half Ceiron Thomas and centre Lachlan Mackay were ruled out at the start of the week following bangs they received last Sunday, meaning third-choice stand-off Christian Lewis-Pratt makes his debut.
Lewis-Pratt, 19, was brought in during the summer predominently as a development player but has been thrust into the limelight at Kingsholm. Scott Barrow comes in for Mackay at inside centre while in the front row, Key and Back have shuffled the pack with Miguel Alonso dropping to the bench and Juan Gomez missing out altogether having pulled up with a knock last weekend.
Mike MacDonald and Phil Swainston come in. England hooker Steve Thompson remains second-choice No 2 behind Andy Titterrell while Alfie To'oala comes into the back row for Kearnan Myall. James Tinknell is on the bench after impressing for the A-league team.
Andre Bester takes in-form Rotherham to Championship promotion favourites Worcester, keen for critics and fans not to look too far ahead. Rotherham have been the surprise package of the division so far with wins over Bristol and Bedford but Bester cautioned: "We are developing a young team and that is a process that can't be forced.
"We're trying to build a sky scraper but we've only just begun to dig the foundations."
Winless Doncaster have winger Matt Williams available for the trip to Bristol but Steve Boden, Matt Challinor and Latu Makaafi are absent through injury.