Delusionofgrandeur made the 40-runner cut before the 1pm deadline after top weight Minella Rocco, and then Vicente, were pulled out because of the heavy ground at Aintree.
Yorkshire-born jockey Henry Brooke takes the ride on the horse who runs in the colours of the McGoldrick Racing syndicate run by Leeds owner Richard Longley.
Smith’s other runner is I Just Know, who won the North Yorkshire National at Catterick in January. He’ll be ridden by stable jockey Danny Cook.
Bingley-based Smith, and her husband Harvey, are seeking a second success after Auroras Encore won five years ago.